Morphine reward in dopamine-deficient mice

Thomas S. Hnasko, Bethany N. Sotak and Richard D. Palmiter ()
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Thomas S. Hnasko: Graduate Program in Neurobiology & Behavior
Bethany N. Sotak: Howard Hughes Medical Institute
Richard D. Palmiter: Howard Hughes Medical Institute

Nature, 2005, vol. 438, issue 7069, 854-857

Abstract: The pleasure principle People take drugs of abuse, at least initially, because of their pleasurable effects; later on, chronic use can lead to addiction. There is a large literature supporting the idea that dopamine release is responsible for the pleasurable effects of morphine, and a general assumption that most drugs of abuse release dopamine, as do other stimuli including food and sex. Dopamine has even been called the ‘pleasure transmitter’. So it is a surprise to find that mice that cannot make dopamine show essentially the same pleasure response as mice that can. This result, based on a behaviour called conditioned place preference as a measure of murine ‘pleasure’, follows on from a finding that dopamine-deficient mice have an intact reward system as measured by a liking for sugar. The link between dopamine and pleasure may not be the ‘given’ it once seemed.

Date: 2005
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DOI: 10.1038/nature04172

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