A colonization factor links Vibrio cholerae environmental survival and human infection

Thomas J. Kirn, Brooke A. Jude and Ronald K. Taylor ()
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Thomas J. Kirn: Dartmouth Medical School
Brooke A. Jude: Dartmouth Medical School
Ronald K. Taylor: Dartmouth Medical School

Nature, 2005, vol. 438, issue 7069, 863-866

Abstract: Survival tricks of a pathogen Vibrio cholerae occupies two contrasting niches: the human small bowel and the aquatic ecosystem. A single protein that enhances survival in both these environments has now been identified — a colonization factor mediating attachment to both zooplankton and epithelial cells by binding to sugars on both surfaces. Considering the broad role for this protein, it may be a promising target for vaccine design.

Date: 2005
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DOI: 10.1038/nature04249

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