The zebrafish dorsal axis is apparent at the four-cell stage

Aniket V. Gore, Shingo Maegawa, Albert Cheong, Patrick C. Gilligan, Eric S. Weinberg and Karuna Sampath ()
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Aniket V. Gore: Temasek Life Sciences Laboratory
Shingo Maegawa: University of Pennsylvania
Albert Cheong: Temasek Life Sciences Laboratory
Patrick C. Gilligan: Temasek Life Sciences Laboratory
Eric S. Weinberg: University of Pennsylvania
Karuna Sampath: Temasek Life Sciences Laboratory

Nature, 2005, vol. 438, issue 7070, 1030-1035

Abstract: Polarity arrives early Several decades of work in frogs and fish led to the hypothesis that ‘localized determinants’ deposited in the egg by the mother establish the dorsal axis of the developing embryo, but the nature of the determinants has remained a mystery. New work in the zebrafish embryo identifies Squint, a Nodal-related transforming growth factor-β signal, as a possible localized dorsal determinant. Squint is present in the two- and four-cell embryo, suggesting that embryonic polarity is established very early on in development. The presence of Squint element in mammals suggests that this mechanism of polarity determination is conserved in the higher vertebrates.

Date: 2005
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DOI: 10.1038/nature04184

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