The Rae1–Nup98 complex prevents aneuploidy by inhibiting securin degradation

Karthik B. Jeganathan, Liviu Malureanu and Jan M. van Deursen ()
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Karthik B. Jeganathan: Mayo College of Medicine
Liviu Malureanu: Mayo College of Medicine
Jan M. van Deursen: Mayo College of Medicine

Nature, 2005, vol. 438, issue 7070, 1036-1039

Abstract: Securing genetic stability The faithful segregation of replicated chromosomes during mitosis is central to maintenance of genetic stability. Two nuclear transport factors, Nup98 and Rae1, which normally regulate transport of macromolecules into and out of the nucleus through nuclear pores, have now been found to perform a novel function in mitosis as a defence against chromosome missegregation. An anaphase inhibitor called securin is targeted for proteolysis by the anaphase-promoting complex when sister chromatid separation becomes due. Nup98 and Rae1 act by preventing the premature degradation of securin, and in their absence the cells become aneuploid, either gaining or losing extra chromosomes.

Date: 2005
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DOI: 10.1038/nature04221

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