Endothelial cells and VEGF in vascular development

Leigh Coultas, Kallayanee Chawengsaksophak and Janet Rossant ()
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Leigh Coultas: The Hospital for Sick Children
Kallayanee Chawengsaksophak: The Hospital for Sick Children
Janet Rossant: The Hospital for Sick Children

Nature, 2005, vol. 438, issue 7070, 937-945

Abstract: Abstract The intricate patterning processes that establish the complex vascular system during development depend on a combination of intrinsic pre-patterning and extrinsic responses to environmental parameters. Mutational studies in mice and fish have shown that the vascular system is highly sensitive to genetic disruption and have identified potential targets for therapeutic interventions. New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stem-cell niches highlight possible side effects of anti-angiogenic therapy and the need for new targets.

Date: 2005
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DOI: 10.1038/nature04479

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