Angiogenesis as a therapeutic target

Napoleone Ferrara () and Robert S. Kerbel
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Napoleone Ferrara: Genentech, 1 DNA Way
Robert S. Kerbel: Sunnybrook and Women's College Health Sciences Centre and the University of Toronto

Nature, 2005, vol. 438, issue 7070, 967-974

Abstract: Abstract Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.

Date: 2005
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DOI: 10.1038/nature04483

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