An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Deborah Palliser, Dipanjan Chowdhury, Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson, David M. Knipe and Judy Lieberman ()
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Deborah Palliser: CBR Institute for Biomedical Research
Dipanjan Chowdhury: CBR Institute for Biomedical Research
Qing-Yin Wang: Department of Microbiology and Molecular Genetics
Sandra J. Lee: Dana Farber Cancer Institute
Roderick T. Bronson: Harvard Medical School
David M. Knipe: Department of Microbiology and Molecular Genetics
Judy Lieberman: CBR Institute for Biomedical Research

Nature, 2006, vol. 439, issue 7072, 89-94

Abstract: RNAi as therapy Gene silencing by small interfering RNAs (siRNAs) is involved in many biological processes. It has the potential to become an important form of therapy, but a major obstacle is the difficulty of delivering siRNA into cells. Palliser et al. now report the efficient delivery of siRNAs in the vagina of mice to protect them from lethal genital herpes simplex virus 2 infection. The development of a microbicide to prevent transmission of sexually transmitted diseases is a high priority for curbing the spread of HIV/AIDS, and herpes simplex virus 2 infection is a cofactor for HIV transmission. This study suggests that it may be possible to use siRNAs as the active component of a vaginal microbicide either prophylactically or to treat sexually transmitted viruses.

Date: 2006
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DOI: 10.1038/nature04263

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