Potentiation of neuroblastoma metastasis by loss of caspase-8

Dwayne G. Stupack (), Tal Teitz, Matthew D. Potter, David Mikolon, Peter J. Houghton, Vincent J. Kidd, Jill M. Lahti () and David A. Cheresh
Additional contact information
Dwayne G. Stupack: The University of California at San Diego
Tal Teitz: Department of Genetics and Tumor Cell Biology
Matthew D. Potter: The University of California at San Diego
David Mikolon: The University of California at San Diego
Peter J. Houghton: St Jude Children's Research Hospital
Vincent J. Kidd: Department of Genetics and Tumor Cell Biology
Jill M. Lahti: Department of Genetics and Tumor Cell Biology
David A. Cheresh: The University of California at San Diego

Nature, 2006, vol. 439, issue 7072, 95-99

Abstract: Caspase 8 in tumours Genetic alterations are common in aggressive neuroblastomas, the most common form of solid tumour in children. In particular the deletion or suppression of the apoptotic protease caspase 8 is common in malignant, disseminated disease. Experiments in neuroblastoma cell lines reveal that caspase 8 has no effect on primary tumour formation; rather it prevents subsequent tissue invasion and metastasis. Acting as a metastasis suppressor by promoting cell death at tumour margins, it prevents the spread of invasive neuroblastoma cells.

Date: 2006
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DOI: 10.1038/nature04323

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