Generation of a functional mammary gland from a single stem cell

Mark Shackleton, François Vaillant, Kaylene J. Simpson, John Stingl, Gordon K. Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J. Lindeman () and Jane E. Visvader ()
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Mark Shackleton: The Walter and Eliza Hall Institute of Medical Research
François Vaillant: The Walter and Eliza Hall Institute of Medical Research
Kaylene J. Simpson: The University of Melbourne
John Stingl: British Columbia Cancer Agency
Gordon K. Smyth: The Walter and Eliza Hall Institute of Medical Research
Marie-Liesse Asselin-Labat: The Walter and Eliza Hall Institute of Medical Research
Li Wu: The Walter and Eliza Hall Institute of Medical Research
Geoffrey J. Lindeman: The Walter and Eliza Hall Institute of Medical Research
Jane E. Visvader: The Walter and Eliza Hall Institute of Medical Research

Nature, 2006, vol. 439, issue 7072, 84-88

Abstract: Mammary stem cells The existence of mammary stem cells has been inferred from genetic analysis of human breast tissue, and from the fact that mouse mammary gland can regenerate from tissue fragments. Two groups now report the isolation of mammary stem cells from mice. Shackleton et al. use a technique based on the introduction of a marker for stem-cell function. A single cell from this population then showed its potency by regenerating an entire mammary gland in vivo. This population of cells is expanded in a pre-malignant mammary tumour model, providing support for the concept of a mammary cancer stem cell. In a paper published online, Stingl et al. report the use of a powerful limiting dilution transplant procedure to purify to near homogeneity a rare subset of adult mouse mammary cells that can individually regenerate an entire mammary gland within six weeks.

Date: 2006
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DOI: 10.1038/nature04372

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