Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Hans Häcker (), Vanessa Redecke, Blagoy Blagoev, Irina Kratchmarova, Li-Chung Hsu, Gang G. Wang, Mark P. Kamps, Eyal Raz, Hermann Wagner, Georg Häcker, Matthias Mann and Michael Karin
Additional contact information
Hans Häcker: School of Medicine
Vanessa Redecke: Department of Medicine
Blagoy Blagoev: University of Southern Denmark
Irina Kratchmarova: University of Southern Denmark
Li-Chung Hsu: School of Medicine
Gang G. Wang: University of California
Mark P. Kamps: University of California
Eyal Raz: Department of Medicine
Hermann Wagner: Technische Universität München
Georg Häcker: Technische Universität München
Matthias Mann: University of Southern Denmark
Michael Karin: School of Medicine

Nature, 2006, vol. 439, issue 7073, 204-207

Abstract: Viral response The innate immune response, a vital defence against viral infections, is initiated when viral products induce type I interferon responses via the activation of Toll-like receptors and various cytoplasmic receptors. Two groups this week report on the properties of a molecule called TRAF3. Its function in immune cells was not previously known, but it is now shown to act as a convergence point for induction of the antiviral response by multiple viral recognition pathways.

Date: 2006
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DOI: 10.1038/nature04369

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