Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Gagik Oganesyan, Supriya K. Saha, Beichu Guo, Jeannie Q. He, Arash Shahangian, Brian Zarnegar, Andrea Perry and Genhong Cheng ()
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Gagik Oganesyan: University of California, Los Angeles
Supriya K. Saha: University of California, Los Angeles
Beichu Guo: University of California, Los Angeles
Jeannie Q. He: University of California, Los Angeles
Arash Shahangian: University of California, Los Angeles
Brian Zarnegar: University of California, Los Angeles
Andrea Perry: University of California, Los Angeles
Genhong Cheng: University of California, Los Angeles

Nature, 2006, vol. 439, issue 7073, 208-211

Abstract: Viral response The innate immune response, a vital defence against viral infections, is initiated when viral products induce type I interferon responses via the activation of Toll-like receptors and various cytoplasmic receptors. Two groups this week report on the properties of a molecule called TRAF3. Its function in immune cells was not previously known, but it is now shown to act as a convergence point for induction of the antiviral response by multiple viral recognition pathways.

Date: 2006
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DOI: 10.1038/nature04374

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