Planar cell polarity signalling couples cell division and morphogenesis during neurulation

Brian Ciruna (), Andreas Jenny, Diana Lee, Marek Mlodzik and Alexander F. Schier ()
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Brian Ciruna: New York University School of Medicine
Andreas Jenny: Cellular and Developmental Biology
Diana Lee: New York University School of Medicine
Marek Mlodzik: Cellular and Developmental Biology
Alexander F. Schier: New York University School of Medicine

Nature, 2006, vol. 439, issue 7073, 220-224

Abstract: Neural tube defects Neural tube closure defects like spina bifida and anencephaly afflict 1 in 1,000 newborns, but the underlying causes of these congenital malformations are largely unknown. Studies in animal models have implicated the planar cell polarity (PCP) signalling pathway as playing a role in neural tube closure during embryogenesis. Ciruna et al. have now uncovered a new mechanism for this process, whereby the PCP protein ‘Van Gogh-like 2’ polarizes neural progenitors along the anterior–posterior axis. This protein is required for intercalation of daughter cells into an intermediate structure called the neural keel formed prior to neural tube closure. The PCP pathway appears to couple cell division to morphogenesis, and malfunction in this system could be a previously unrecognized cause of neural tube closure defects.

Date: 2006
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DOI: 10.1038/nature04375

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