Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki, Marcelo A. Christoffolete, Brian W. Kim, Hiroyuki Sato, Nadia Messaddeq, John W. Harney, Osamu Ezaki, Tatsuhiko Kodama, Kristina Schoonjans, Antonio C. Bianco and Johan Auwerx ()
Additional contact information
Mitsuhiro Watanabe: CNRS/INSERM/ULP
Sander M. Houten: CNRS/INSERM/ULP
Chikage Mataki: CNRS/INSERM/ULP
Marcelo A. Christoffolete: Brigham and Women's Hospital and Harvard Medical School
Brian W. Kim: Brigham and Women's Hospital and Harvard Medical School
Hiroyuki Sato: CNRS/INSERM/ULP
Nadia Messaddeq: CNRS/INSERM/ULP
John W. Harney: Brigham and Women's Hospital and Harvard Medical School
Osamu Ezaki: Division of Clinical Nutrition, National Institute of Health and Nutrition
Tatsuhiko Kodama: RCAST, University of Tokyo
Kristina Schoonjans: CNRS/INSERM/ULP
Antonio C. Bianco: Brigham and Women's Hospital and Harvard Medical School
Johan Auwerx: CNRS/INSERM/ULP

Nature, 2006, vol. 439, issue 7075, 484-489

Abstract: Turn up the heat Bile acids are known to mediate dietary lipid absorption and cholesterol catabolism, and recently an important signalling role emerged. Now they have been found to increase energy expenditure in brown adipose tissue and human skeletal muscle. As bile acid signalling may drive diet-induced heat production, it is a possible therapeutic target for the control of energy homeostasis.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature04330 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:439:y:2006:i:7075:d:10.1038_nature04330

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04330

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().