Architecture of ribonucleoprotein complexes in influenza A virus particles

Takeshi Noda, Hiroshi Sagara, Albert Yen, Ayato Takada, Hiroshi Kida, R. Holland Cheng and Yoshihiro Kawaoka ()
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Takeshi Noda: University of Tokyo
Hiroshi Sagara: Institute of Medical Science, University of Tokyo
Albert Yen: Karolinska Institute
Ayato Takada: Japan Science and Technology Agency
Hiroshi Kida: Graduate School of Veterinary Medicine, Hokkaido University
R. Holland Cheng: Karolinska Institute
Yoshihiro Kawaoka: University of Tokyo

Nature, 2006, vol. 439, issue 7075, 490-492

Abstract: Flu virus: pieces of eight The influenza virus is unusual in that its genome is fragmented, and the mechanism that reconstitutes the genome in viral progeny is largely unknown. A new electron microscopy study reveals that each budding influenza virus particle contains a central rod of genetic material, surrounded by seven peripheral rods in a reproducible pattern. Prior to this work it was commonly thought that viral particles consisted of eight randomly selected RNA segments. This high level of organization could be a weak point in the virus's defences that might be exploited by new antiviral drugs.

Date: 2006
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DOI: 10.1038/nature04378

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