Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

Gregor B. Adams, Karissa T. Chabner, Ian R. Alley, Douglas P. Olson, Zbigniew M. Szczepiorkowski, Mark C. Poznansky, Claudine H. Kos, Martin R. Pollak, Edward M. Brown and David T. Scadden ()
Additional contact information
Gregor B. Adams: Center for Regenerative Medicine
Karissa T. Chabner: Center for Regenerative Medicine
Ian R. Alley: Center for Regenerative Medicine
Douglas P. Olson: Center for Regenerative Medicine
Zbigniew M. Szczepiorkowski: Center for Regenerative Medicine
Mark C. Poznansky: Center for Regenerative Medicine
Claudine H. Kos: Renal Division
Martin R. Pollak: Renal Division
Edward M. Brown: Brigham and Women's Hospital, Harvard Medical School
David T. Scadden: Center for Regenerative Medicine

Nature, 2006, vol. 439, issue 7076, 599-603

Abstract: Stem-cell guidance Haematopoietic stem cells ‘home’ to the bone marrow during embryogenesis and after bone marrow transplants. With the exception of integrins, the molecules that mediate this process are largely unknown. Now Adams et al. have identified another factor essential for homing, a membrane-spanning molecule called calcium-sensing receptor (CaR). Cells lacking CaR divide normally, but the newly formed cells are unable to migrate and home to the bone marrow. This newly recognized participant in the localization and engraftment of stem cells provides a potential target for affecting that process.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature04247 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:439:y:2006:i:7076:d:10.1038_nature04247

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04247

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().