Identification of pathways regulating cell size and cell-cycle progression by RNAi

Mikael Björklund, Minna Taipale (), Markku Varjosalo, Juha Saharinen, Juhani Lahdenperä and Jussi Taipale ()
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Mikael Björklund: University of Helsinki
Minna Taipale: University of Helsinki
Markku Varjosalo: University of Helsinki
Juha Saharinen: National Public Health Institute
Juhani Lahdenperä: University of Helsinki
Jussi Taipale: University of Helsinki

Nature, 2006, vol. 439, issue 7079, 1009-1013

Abstract: Cell cycle paths Recent advances in our understanding of control of the eukaryotic cell cycle have relied on loss-of-function analyses of unicellular yeasts. But in multicellular organisms there are additional control mechanisms that regulate cell-cycle progression in the G1 phase, and specify the size of the organism and its constituent organs. An RNA interference (RNAi) screening for pathways regulating cell size and cell cycle in Drosophila has now identified genes that specifically control cell size, cytokinesis, and cell death/apoptosis. The panel of genes involved in cell-cycle control will serve as a basis for a systems biology approach to analysis of the metazoan cell cycle.

Date: 2006
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DOI: 10.1038/nature04469

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