Introns and the origin of nucleus–cytosol compartmentalization

William Martin () and Eugene V. Koonin
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William Martin: University of Düsseldorf
Eugene V. Koonin: National Library of Medicine, National Institutes of Health

Nature, 2006, vol. 440, issue 7080, 41-45

Abstract: Abstract The origin of the eukaryotic nucleus marked a seminal evolutionary transition. We propose that the nuclear envelope's incipient function was to allow mRNA splicing, which is slow, to go to completion so that translation, which is fast, would occur only on mRNA with intact reading frames. The rapid, fortuitous spread of introns following the origin of mitochondria is adduced as the selective pressure that forged nucleus–cytosol compartmentalization.

Date: 2006
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DOI: 10.1038/nature04531

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