V1 spinal neurons regulate the speed of vertebrate locomotor outputs

Simon Gosgnach, Guillermo M. Lanuza, Simon J. B. Butt, Harald Saueressig, Ying Zhang, Tomoko Velasquez, Dieter Riethmacher, Edward M. Callaway, Ole Kiehn and Martyn Goulding ()
Additional contact information
Simon Gosgnach: Molecular Neurobiology Laboratory
Guillermo M. Lanuza: Molecular Neurobiology Laboratory
Simon J. B. Butt: The Karolinska Institute
Harald Saueressig: Molecular Neurobiology Laboratory
Ying Zhang: Molecular Neurobiology Laboratory
Tomoko Velasquez: Molecular Neurobiology Laboratory
Dieter Riethmacher: University of Hamburg
Edward M. Callaway: The Salk Institute for Biological Studies
Ole Kiehn: The Karolinska Institute
Martyn Goulding: Molecular Neurobiology Laboratory

Nature, 2006, vol. 440, issue 7081, 215-219

Abstract: Walking in water Complex movements such as walking or swimming are produced by networks of nerve cells embedded in the spinal cord. A new study in mice has identified, for the first time, a subset of such nerve cells that controls the speed of locomotion. A unique combination of genetic and electrophysiological techniques reveals how these cells help set the rhythmic activity of spinal cord neurons. This work should be of interest to those studying neurological disorders. Intriguingly the V1 neurons that serve this function are conserved between swimming and walking vertebrates.

Date: 2006
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DOI: 10.1038/nature04545

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