Expression profiling in primates reveals a rapid evolution of human transcription factors

Yoav Gilad (), Alicia Oshlack, Gordon K. Smyth, Terence P. Speed and Kevin P. White ()
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Yoav Gilad: Yale University
Alicia Oshlack: Walter and Eliza Hall Institute of Medical Research
Gordon K. Smyth: Walter and Eliza Hall Institute of Medical Research
Terence P. Speed: Walter and Eliza Hall Institute of Medical Research
Kevin P. White: Yale University

Nature, 2006, vol. 440, issue 7081, 242-245

Abstract: Express yourself Much has been written about the similarity between the human genome and those of the great apes. But as well as gene sequence, the manifestation of a genome in flesh and blood depends on gene expression patterns. Now using a multispecies cDNA array to compare human gene expression patterns to those in chimpanzees, orangutans and rhesus macaques, it is possible to identify individual genes subject to fast and slow expression-rate evolution. Some genes have been expressed at constant levels across the 70 million years of evolution encompassed by these species: these include genes associated with liver carcinoma, suggesting that other disease candidate genes might be found amongst genes with conserved expression. In contrast to these stable genes, positive selection in the human lineage occurs disproportionately on the very class of genes thought to be most likely to lead to divergence at the organismal level, the genes for transcription factors.

Date: 2006
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DOI: 10.1038/nature04559

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