RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

Sylvain Lesné, Ming Teng Koh, Linda Kotilinek, Rakez Kayed, Charles G. Glabe, Austin Yang, Michela Gallagher and Karen H. Ashe ()
Additional contact information
Sylvain Lesné: Departments of Neurology
Ming Teng Koh: Johns Hopkins University
Linda Kotilinek: Departments of Neurology
Rakez Kayed: University of California
Charles G. Glabe: University of California
Austin Yang: University of Southern California
Michela Gallagher: Johns Hopkins University
Karen H. Ashe: Departments of Neurology

Nature, 2006, vol. 440, issue 7082, 352-357

Abstract: Early Warning Of Alzheimer's Poor memory function has been noted in individuals that developed Alzheimer's disease up to 15 years before the eventual diagnosis of the condition. Experiments in a mouse model for the disease have now tracked down a possible cause for this early symptom: the extracellular accumulation of a soluble amyloid-β peptide assembly, dubbed Aβ*. When Aβ* is isolated from these mice and injected into rats, the rats also experience temporary memory deterioration independent of plaque formation or neuronal loss, the classic hallmarks of Alzheimer's. This work points to Aβ* as a potential diagnostic, and raises the possibility that by targeting it early it may be possible to prevent or delay the permanent changes characteristic of the later stages of the disease.

Date: 2006
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DOI: 10.1038/nature04533

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