The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation

Jin-Won Lee and John D. Helmann ()
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Jin-Won Lee: Cornell University
John D. Helmann: Cornell University

Nature, 2006, vol. 440, issue 7082, 363-367

Abstract: The protein PerR, from Bacillus subtilis, senses peroxides through a mechanism that involves the incorporation of one oxygen atom into histidine residues in the active site. The reduction of hydrogen peroxide by metal ions contributes to the inactivation of enzymes in vivo, but this is the first time that this process has been shown to be involved in the sensing of peroxide.

Date: 2006
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DOI: 10.1038/nature04537

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