Running rings around the spindle

Deepa Nath

Nature, 2006, vol. 440, issue 7083, 434-434

Abstract: Hang on in there A long-standing mystery of mitosis research is the mechanism that transports chromosomes to the nuclear-spindle poles during anaphase. The chromosomes seem to gain their objective by clinging on to the kinetochore microtubule polymers despite the fact that they are disassembling at the time. Fluorescence microscopy has now been used to produce movies and electron micrographs that show how it's done. The microtubule polymer disassembles via a conformational change that pushes the Dam1 ring complex, an important microtubule binding element in the budding yeast kinetochore, along its lattice. This elegant mechanism may be the key to the conversion of force generated by microtubule depolymerization into the chromosome movements seen in mitosis.

Date: 2006
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DOI: 10.1038/440434a

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