The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends

Stefan Westermann, Hong-Wei Wang, Agustin Avila-Sakar, David G. Drubin, Eva Nogales and Georjana Barnes ()
Additional contact information
Stefan Westermann: Department of Molecular and Cell Biology
Hong-Wei Wang: Lawrence Berkeley National Laboratory
Agustin Avila-Sakar: Lawrence Berkeley National Laboratory
David G. Drubin: Department of Molecular and Cell Biology
Eva Nogales: Department of Molecular and Cell Biology
Georjana Barnes: Department of Molecular and Cell Biology

Nature, 2006, vol. 440, issue 7083, 565-569

Abstract: Hang on in there A long-standing mystery of mitosis research is the mechanism that transports chromosomes to the nuclear-spindle poles during anaphase. The chromosomes seem to gain their objective by clinging on to the kinetochore microtubule polymers despite the fact that they are disassembling at the time. Fluorescence microscopy has now been used to produce movies and electron micrographs that show how it's done. The microtubule polymer disassembles via a conformational change that pushes the Dam1 ring complex, an important microtubule binding element in the budding yeast kinetochore, along its lattice. This elegant mechanism may be the key to the conversion of force generated by microtubule depolymerization into the chromosome movements seen in mitosis.

Date: 2006
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature04409 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:440:y:2006:i:7083:d:10.1038_nature04409

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04409

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().