Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation

Meenakshi K. Doma and Roy Parker ()
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Meenakshi K. Doma: University of Arizona
Roy Parker: University of Arizona

Nature, 2006, vol. 440, issue 7083, 561-564

Abstract: This study identifies a third eukaryotic quality-control mechanism that ensures only functional mRNAs are translated — 'no-go decay'. This system recognizes and degrades mRNAs with stalled translation elongation complexes, which might occur if the mRNA is damaged.

Date: 2006
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DOI: 10.1038/nature04530

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