An excitable gene regulatory circuit induces transient cellular differentiation

Gürol M. Süel, Jordi Garcia-Ojalvo, Louisa M. Liberman and Michael B. Elowitz ()
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Gürol M. Süel: California Institute of Technology
Jordi Garcia-Ojalvo: Universitat Politècnica de Catalunya
Louisa M. Liberman: California Institute of Technology
Michael B. Elowitz: California Institute of Technology

Nature, 2006, vol. 440, issue 7083, 545-550

Abstract: Time-lapse imaging is used to follow the activity of several promoters that regulate competence genes in Bacillus subtilis, and the data used to develop a mathematical model of the gene circuitry — revealing that excitable dynamics underlies the positive and negative feedback loops that regulate entry into, and exit from, competence in an individual cell.

Date: 2006
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DOI: 10.1038/nature04588

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