Human chromosome 11 DNA sequence and analysis including novel gene identification

Todd D. Taylor (), Hideki Noguchi, Yasushi Totoki, Atsushi Toyoda, Yoko Kuroki, Ken Dewar, Christine Lloyd, Takehiko Itoh, Tadayuki Takeda, Dae-Won Kim, Xinwei She, Karen F. Barlow, Toby Bloom, Elspeth Bruford, Jean L. Chang, Christina A. Cuomo, Evan Eichler, Michael G. FitzGerald, David B. Jaffe, Kurt LaButti, Robert Nicol, Hong-Seog Park, Christopher Seaman, Carrie Sougnez, Xiaoping Yang, Andrew R. Zimmer, Michael C. Zody, Bruce W. Birren, Chad Nusbaum, Asao Fujiyama, Masahira Hattori, Jane Rogers, Eric S. Lander and Yoshiyuki Sakaki ()
Additional contact information
Todd D. Taylor: RIKEN Genomic Sciences Center
Hideki Noguchi: RIKEN Genomic Sciences Center
Yasushi Totoki: RIKEN Genomic Sciences Center
Atsushi Toyoda: RIKEN Genomic Sciences Center
Yoko Kuroki: RIKEN Genomic Sciences Center
Ken Dewar: Broad Institute of MIT and Harvard
Christine Lloyd: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Takehiko Itoh: Mitsubishi Research Institute, Inc.
Tadayuki Takeda: RIKEN Genomic Sciences Center
Dae-Won Kim: Korea Research Institute of Bioscience & Biotechnology
Xinwei She: University of Washington, Genome Sciences, HSB K336B
Karen F. Barlow: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Toby Bloom: Broad Institute of MIT and Harvard
Elspeth Bruford: University College London
Jean L. Chang: Broad Institute of MIT and Harvard
Christina A. Cuomo: Broad Institute of MIT and Harvard
Evan Eichler: University of Washington, Genome Sciences, HSB K336B
Michael G. FitzGerald: Broad Institute of MIT and Harvard
David B. Jaffe: Broad Institute of MIT and Harvard
Kurt LaButti: Broad Institute of MIT and Harvard
Robert Nicol: Broad Institute of MIT and Harvard
Hong-Seog Park: Korea Research Institute of Bioscience & Biotechnology
Christopher Seaman: Broad Institute of MIT and Harvard
Carrie Sougnez: Broad Institute of MIT and Harvard
Xiaoping Yang: Broad Institute of MIT and Harvard
Andrew R. Zimmer: Broad Institute of MIT and Harvard
Michael C. Zody: Broad Institute of MIT and Harvard
Bruce W. Birren: Broad Institute of MIT and Harvard
Chad Nusbaum: Broad Institute of MIT and Harvard
Asao Fujiyama: RIKEN Genomic Sciences Center
Masahira Hattori: RIKEN Genomic Sciences Center
Jane Rogers: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Eric S. Lander: Broad Institute of MIT and Harvard
Yoshiyuki Sakaki: RIKEN Genomic Sciences Center

Nature, 2006, vol. 440, issue 7083, 497-500

Abstract: Abstract Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here—nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence—provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature04632 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:440:y:2006:i:7083:d:10.1038_nature04632

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04632

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().