Glutamate receptors at atomic resolution

Mark L. Mayer ()
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Mark L. Mayer: Building 35, Room 3B1002, Porter Neuroscience Research Center

Nature, 2006, vol. 440, issue 7083, 456-462

Abstract: Abstract At synapses throughout the brain and spinal cord, the amino-acid glutamate is the major excitatory neurotransmitter. During evolution, a family of glutamate-receptor ion channels seems to have been assembled from a kit consisting of discrete ligand-binding, ion-channel, modulatory and cytoplasmic domains. Crystallographic studies that exploit this unique architecture have greatly aided structural analysis of the ligand-binding core, but the results also pose a formidable challenge, namely that of resolving the allosteric mechanisms by which individual domains communicate and function in an intact receptor.

Date: 2006
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DOI: 10.1038/nature04709

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