KATP channels as molecular sensors of cellular metabolism

Colin G. Nichols ()
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Colin G. Nichols: Washington University School of Medicine

Nature, 2006, vol. 440, issue 7083, 470-476

Abstract: Abstract In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of KATP has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.

Date: 2006
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DOI: 10.1038/nature04711

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