Regulation of cancer cell migration and bone metastasis by RANKL

D. Holstead Jones, Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki, Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger ()
Additional contact information
D. Holstead Jones: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Tomoki Nakashima: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Otto H. Sanchez: University Health Network
Ivona Kozieradzki: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Svetlana V. Komarova: McGill University
Ildiko Sarosi: Amgen Inc.
Sean Morony: Amgen Inc.
Evelyn Rubin: Department of Medical Biophysics
Renu Sarao: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Carlo V. Hojilla: University Health Network
Vukoslav Komnenovic: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Young-Yun Kong: Pohang University of Science and Technology
Martin Schreiber: Medical University of Vienna
S. Jeffrey Dixon: The University of Western Ontario
Stephen M. Sims: The University of Western Ontario
Rama Khokha: Department of Medical Biophysics
Teiji Wada: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Josef M. Penninger: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences

Nature, 2006, vol. 440, issue 7084, 692-696

Abstract: Cancer cells that express the receptor protein RANK migrate to bone tissue where the RANK ligand, RANKL, is found. This contributes to bone metastases and offers a potential therapeutic approach to prevent cancer metastases.

Date: 2006
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DOI: 10.1038/nature04524

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