Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

Susana Gonzalez, Peter Klatt, Sonia Delgado, Esther Conde, Fernando Lopez-Rios, Montserrat Sanchez-Cespedes, Juan Mendez, Francisco Antequera and Manuel Serrano ()
Additional contact information
Susana Gonzalez: Tumor Suppression Group
Peter Klatt: Tumor Suppression Group
Sonia Delgado: CSIC/Universidad de Salamanca
Esther Conde: Lung Cancer Group
Fernando Lopez-Rios: Hospital Universitario “12 de Octubre”
Montserrat Sanchez-Cespedes: Lung Cancer Group
Juan Mendez: Spanish National Cancer Research Center (CNIO)
Francisco Antequera: CSIC/Universidad de Salamanca
Manuel Serrano: Tumor Suppression Group

Nature, 2006, vol. 440, issue 7084, 702-706

Abstract: Cancer target The INK4/ARF locus encodes three tumour suppressors and is frequently inactivated in human cancer. Gonzalez et al. have now identified a possible DNA replication origin at the INK4/ARF locus that can mediate its transcriptional silencing, for example when the replication protein Cdc6 is overexpressed as seen in some human tumours. This points to Cdc6 as an alternative target for the inactivation of INK4/ARF in human cancer.

Date: 2006
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature04585 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:440:y:2006:i:7084:d:10.1038_nature04585

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04585

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().