Analysis of a RanGTP-regulated gradient in mitotic somatic cells

Petr Kaláb, Arnd Pralle, Ehud Y. Isacoff, Rebecca Heald () and Karsten Weis ()
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Petr Kaláb: University of California
Arnd Pralle: University of California
Ehud Y. Isacoff: University of California
Rebecca Heald: University of California
Karsten Weis: University of California

Nature, 2006, vol. 440, issue 7084, 697-701

Abstract: A fluorescence resonance energy transfer biosensor called Rango enables examination of the Ran–importin-β system in cells. Small changes in RanGTP concentration tip the balance between positive and negative mitotic regulators, thereby promoting spindle assembly and function.

Date: 2006
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DOI: 10.1038/nature04589

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