Analysis of the DNA sequence and duplication history of human chromosome 15

Michael C. Zody (), Manuel Garber, Ted Sharpe, Sarah K. Young, Lee Rowen, Keith O'Neill, Charles A. Whittaker, Michael Kamal, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Chinnappa D. Kodira, Anup Madan, Shizhen Qin, Xiaoping Yang, Nissa Abbasi, Amr Abouelleil, Harindra M. Arachchi, Lida Baradarani, Brian Birditt, Scott Bloom, Toby Bloom, Mark L. Borowsky, Jeremy Burke, Jonathan Butler, April Cook, Kurt DeArellano, David DeCaprio, Lester Dorris, Monica Dors, Evan E. Eichler, Reinhard Engels, Jessica Fahey, Peter Fleetwood, Cynthia Friedman, Gary Gearin, Jennifer L. Hall, Grace Hensley, Ericka Johnson, Charlien Jones, Asha Kamat, Amardeep Kaur, Devin P. Locke, Anuradha Madan, Glen Munson, David B. Jaffe, Annie Lui, Pendexter Macdonald, Evan Mauceli, Jerome W. Naylor, Ryan Nesbitt, Robert Nicol, Sinéad B. O'Leary, Amber Ratcliffe, Steven Rounsley, Xinwei She, Katherine M. B. Sneddon, Sandra Stewart, Carrie Sougnez, Sabrina M. Stone, Kerri Topham, Dascena Vincent, Shunguang Wang, Andrew R. Zimmer, Bruce W. Birren, Leroy Hood, Eric S. Lander and Chad Nusbaum ()
Additional contact information
Michael C. Zody: Broad Institute of MIT and Harvard
Manuel Garber: Broad Institute of MIT and Harvard
Ted Sharpe: Broad Institute of MIT and Harvard
Sarah K. Young: Broad Institute of MIT and Harvard
Lee Rowen: Institute for Systems Biology
Keith O'Neill: Broad Institute of MIT and Harvard
Charles A. Whittaker: Broad Institute of MIT and Harvard
Michael Kamal: Broad Institute of MIT and Harvard
Jean L. Chang: Broad Institute of MIT and Harvard
Christina A. Cuomo: Broad Institute of MIT and Harvard
Ken Dewar: Broad Institute of MIT and Harvard
Michael G. FitzGerald: Broad Institute of MIT and Harvard
Chinnappa D. Kodira: Broad Institute of MIT and Harvard
Anup Madan: Institute for Systems Biology
Shizhen Qin: Institute for Systems Biology
Xiaoping Yang: Broad Institute of MIT and Harvard
Nissa Abbasi: Institute for Systems Biology
Amr Abouelleil: Broad Institute of MIT and Harvard
Harindra M. Arachchi: Broad Institute of MIT and Harvard
Lida Baradarani: Institute for Systems Biology
Brian Birditt: Institute for Systems Biology
Scott Bloom: Institute for Systems Biology
Toby Bloom: Broad Institute of MIT and Harvard
Mark L. Borowsky: Broad Institute of MIT and Harvard
Jeremy Burke: Institute for Systems Biology
Jonathan Butler: Broad Institute of MIT and Harvard
April Cook: Broad Institute of MIT and Harvard
Kurt DeArellano: Broad Institute of MIT and Harvard
David DeCaprio: Broad Institute of MIT and Harvard
Lester Dorris: Broad Institute of MIT and Harvard
Monica Dors: Institute for Systems Biology
Evan E. Eichler: University of Washington
Reinhard Engels: Broad Institute of MIT and Harvard
Jessica Fahey: Institute for Systems Biology
Peter Fleetwood: Institute for Systems Biology
Cynthia Friedman: Fred Hutchinson Cancer Research Center
Gary Gearin: Broad Institute of MIT and Harvard
Jennifer L. Hall: Broad Institute of MIT and Harvard
Grace Hensley: Institute for Systems Biology
Ericka Johnson: Institute for Systems Biology
Charlien Jones: Broad Institute of MIT and Harvard
Asha Kamat: Broad Institute of MIT and Harvard
Amardeep Kaur: Institute for Systems Biology
Devin P. Locke: University of Washington
Anuradha Madan: Institute for Systems Biology
Glen Munson: Broad Institute of MIT and Harvard
David B. Jaffe: Broad Institute of MIT and Harvard
Annie Lui: Broad Institute of MIT and Harvard
Pendexter Macdonald: Broad Institute of MIT and Harvard
Evan Mauceli: Broad Institute of MIT and Harvard
Jerome W. Naylor: Broad Institute of MIT and Harvard
Ryan Nesbitt: Institute for Systems Biology
Robert Nicol: Broad Institute of MIT and Harvard
Sinéad B. O'Leary: Broad Institute of MIT and Harvard
Amber Ratcliffe: Institute for Systems Biology
Steven Rounsley: Broad Institute of MIT and Harvard
Xinwei She: University of Washington
Katherine M. B. Sneddon: University College London
Sandra Stewart: Institute for Systems Biology
Carrie Sougnez: Broad Institute of MIT and Harvard
Sabrina M. Stone: Broad Institute of MIT and Harvard
Kerri Topham: Broad Institute of MIT and Harvard
Dascena Vincent: Institute for Systems Biology
Shunguang Wang: Broad Institute of MIT and Harvard
Andrew R. Zimmer: Broad Institute of MIT and Harvard
Bruce W. Birren: Broad Institute of MIT and Harvard
Leroy Hood: Institute for Systems Biology
Eric S. Lander: Broad Institute of MIT and Harvard
Chad Nusbaum: Broad Institute of MIT and Harvard

Nature, 2006, vol. 440, issue 7084, 671-675

Abstract: First fifteen Analysis of human chromosome 15 shows it to be highly segmentally duplicated. The duplications are unusual in that they are clustered in two distinct regions, rather than distributed all along the chromosome. Recombination within the duplications at one of these regions can give rise to deletions that cause Prader–Willi and Angelman syndromes.

Date: 2006
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DOI: 10.1038/nature04601

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