Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3

Frédéric Darios and Bazbek Davletov ()
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Frédéric Darios: MRC Laboratory of Molecular Biology
Bazbek Davletov: MRC Laboratory of Molecular Biology

Nature, 2006, vol. 440, issue 7085, 813-817

Abstract: A neuronal repair kit Omega-3 and omega-6 fatty acids are commonly recommended as dietary supplements, especially during pregnancy and in childhood, as they are thought to support brain development. In a screening assay in growing nerve cells, the small membrane protein syntaxin 3 has now been identified as the target for the action of these essential nutrients. Omega-3 and omega-6 fatty acids activate syntaxin-3 allowing growth of neuronal extensions, an essential process in brain development. This finding raises the prospect of using syntaxin-3 for identification of more potent compounds able to accelerate neuronal repair following injury.

Date: 2006
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DOI: 10.1038/nature04598

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