Type ID unconventional myosin controls left–right asymmetry in Drosophila

Pauline Spéder, Géza Ádám and Stéphane Noselli ()
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Pauline Spéder: University of Nice Sophia-Antipolis
Géza Ádám: University of Nice Sophia-Antipolis
Stéphane Noselli: University of Nice Sophia-Antipolis

Nature, 2006, vol. 440, issue 7085, 803-807

Abstract: All right now From flies to humans, the left and right side of the body plan differs. Exactly how symmetry is broken in the early embryo is a mystery. But now two groups working independently report a genetic defect in the fly that may help uncover the mechanism. Both groups studied a mutant with reversed looping of the viscera, and discovered that the mutation lies in an unconventional myosin. Myosin directs right-handed looping and represses the default left-handed fate. This discovery now links actin-based molecular motors and the actin cytoskeleton to left–right patterning in vertebrates.

Date: 2006
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DOI: 10.1038/nature04623

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