An unconventional myosin in Drosophila reverses the default handedness in visceral organs

Shunya Hozumi, Reo Maeda, Kiichiro Taniguchi, Maiko Kanai, Syuichi Shirakabe, Takeshi Sasamura, Pauline Spéder, Stéphane Noselli, Toshiro Aigaki, Ryutaro Murakami and Kenji Matsuno ()
Additional contact information
Shunya Hozumi: Department of Biological Science and Technology
Reo Maeda: Department of Biological Science and Technology
Kiichiro Taniguchi: Department of Biological Science and Technology
Maiko Kanai: Department of Biological Science and Technology
Syuichi Shirakabe: Department of Biological Science and Technology
Takeshi Sasamura: Department of Biological Science and Technology
Pauline Spéder: University of Nice Sophia-Antipolis
Stéphane Noselli: University of Nice Sophia-Antipolis
Toshiro Aigaki: Tokyo Metropolitan University
Ryutaro Murakami: Yamaguchi University
Kenji Matsuno: Department of Biological Science and Technology

Nature, 2006, vol. 440, issue 7085, 798-802

Abstract: All right now From flies to humans, the left and right side of the body plan differs. Exactly how symmetry is broken in the early embryo is a mystery. But now two groups working independently report a genetic defect in the fly that may help uncover the mechanism. Both groups studied a mutant with reversed looping of the viscera, and discovered that the mutation lies in an unconventional myosin. Myosin directs right-handed looping and represses the default left-handed fate. This discovery now links actin-based molecular motors and the actin cytoskeleton to left–right patterning in vertebrates.

Date: 2006
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DOI: 10.1038/nature04625

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