The reversibility of mitotic exit in vertebrate cells

Tamara A. Potapova, John R. Daum, Bradley D. Pittman, Joanna R. Hudson, Tara N. Jones, David L. Satinover, P. Todd Stukenberg and Gary J. Gorbsky ()
Additional contact information
Tamara A. Potapova: Oklahoma Medical Research Foundation
John R. Daum: Oklahoma Medical Research Foundation
Bradley D. Pittman: Oklahoma Medical Research Foundation
Joanna R. Hudson: Oklahoma Medical Research Foundation
Tara N. Jones: Oklahoma Medical Research Foundation
David L. Satinover: University of Virginia Medical School
P. Todd Stukenberg: University of Virginia Medical School
Gary J. Gorbsky: Oklahoma Medical Research Foundation

Nature, 2006, vol. 440, issue 7086, 954-958

Abstract: Cells proceed through the cell cycle in a highly ordered and unidirectional manner; however, if the degradation of cyclin B is prevented as cells exit mitosis and its associated Cdk1 kinase activity restored, cells can reverse back to M phase.

Date: 2006
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DOI: 10.1038/nature04652

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