Pharmaco-metabonomic phenotyping and personalized drug treatment

T. Andrew Clayton, John C. Lindon, Olivier Cloarec, Henrik Antti, Claude Charuel, Gilles Hanton, Jean-Pierre Provost, Jean-Loïc Le Net, David Baker, Rosalind J. Walley, Jeremy R. Everett and Jeremy K. Nicholson ()
Additional contact information
T. Andrew Clayton: Sir Alexander Fleming Building, Imperial College London
John C. Lindon: Sir Alexander Fleming Building, Imperial College London
Olivier Cloarec: Sir Alexander Fleming Building, Imperial College London
Henrik Antti: Umeå University
Claude Charuel: Centre de Recherche
Gilles Hanton: Centre de Recherche
Jean-Pierre Provost: Centre de Recherche
Jean-Loïc Le Net: Centre de Recherche
David Baker: Pfizer Inc.
Rosalind J. Walley: Pfizer Global Research & Development
Jeremy R. Everett: Pfizer Global Research & Development
Jeremy K. Nicholson: Sir Alexander Fleming Building, Imperial College London

Nature, 2006, vol. 440, issue 7087, 1073-1077

Abstract: Medicines for one We may one day benefit from 'personalized medicine', which will involve analysing key characteristics of an individual and predicting which drugs will be effective for that patient. Although the pharmacogenomic approach looked promising, its usefulness is limited as it does not take account of potentially important environmental factors. Enter 'pharmaco-metabonomics', which uses a combination of pre-dose metabolite profiling and chemometrics to model and predict the response of an individual. A 'proof-of-principle' for this approach, in which the metabolic effects of paracetamol in rats were predicted, is published this week. This approach involves the analysis of a patient's metabolic phenotype, which is influenced not only by genotype but also by factors such as nutritional status, age and disease, so it could be an important step towards personalized human healthcare.

Date: 2006
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DOI: 10.1038/nature04648

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