Pluripotency of spermatogonial stem cells from adult mouse testis

Kaomei Guan, Karim Nayernia, Lars S. Maier, Stefan Wagner, Ralf Dressel, Jae Ho Lee, Jessica Nolte, Frieder Wolf, Manyu Li, Wolfgang Engel () and Gerd Hasenfuss ()
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Kaomei Guan: Georg-August-University of Göttingen
Karim Nayernia: Institute of Human Genetics
Lars S. Maier: Georg-August-University of Göttingen
Stefan Wagner: Georg-August-University of Göttingen
Ralf Dressel: Georg-August-University of Göttingen
Jae Ho Lee: Institute of Human Genetics
Jessica Nolte: Institute of Human Genetics
Frieder Wolf: Georg-August-University of Göttingen
Manyu Li: Institute of Human Genetics
Wolfgang Engel: Institute of Human Genetics
Gerd Hasenfuss: Georg-August-University of Göttingen

Nature, 2006, vol. 440, issue 7088, 1199-1203

Abstract: Match practice Some cells in newborn mouse testis are — like embryonic stem cells — able to generate many different tissue types. Guan et al. have discovered that these cells persist in the adult. Sperm-producing stem cells from mouse adult testis can grow as heart, nerve or muscle cells in the right conditions. If similar multipotent adult germline stem cells (maGSCs) can be isolated from humans — perhaps by simple testicular biopsy — they might provide an alternative source of genetically matched therapeutic cells.

Date: 2006
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DOI: 10.1038/nature04697

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