The DNA sequence, annotation and analysis of human chromosome 3

Muzny, Donna M.; Scherer, Steven E.; Kaul, Rajinder; Wang, Jing; Yu, Jun; Sudbrak, Ralf; Buhay, Christian J.; Chen, Rui; Cree, Andrew; Ding, Yan; Dugan-Rocha, Shannon; Gill, Rachel; Gunaratne, Preethi; Harris, R. Alan; Hawes, Alicia C.; Hernandez, Judith; Hodgson, Anne V.; Hume, Jennifer; Jackson, Andrew; Khan, Ziad Mohid; Kovar-Smith, Christie; Lewis, Lora R.; Lozado, Ryan J.; Metzker, Michael L.; Milosavljevic, Aleksandar; Miner, George R.; Morgan, Margaret B.; Nazareth, Lynne V.; Scott, Graham; Sodergren, Erica; Song, Xing-Zhi; Steffen, David; Wei, Sharon; Wheeler, David A.; Wright, Mathew W.; Worley, Kim C.; Yuan, Ye; Zhang, Zhengdong; Adams, Charles Q.; Ansari-Lari, M. Ali; Ayele, Mulu; Brown, Mary J.; Chen, Guan; Chen, Zhijian; Clendenning, James; Clerc-Blankenburg, Kerstin P.; Chen, Runsheng; Chen, Zhu; Davis, Clay; Delgado, Oliver; Dinh, Huyen H.; Dong, Wei; Draper, Heather; Ernst, Stephen; Fu, Gang; Gonzalez-Garay, Manuel L.; Garcia, Dawn K.; Gillett, Will; Gu, Jun; Hao, Bailin; Haugen, Eric; Havlak, Paul; He, Xin; Hennig, Steffen; Hu, Songnian; Huang, Wei; Jackson, Laronda R.; Jacob, Leni S.; Kelly, Susan H.; Kube, Michael; Levy, Ruth; Li, Zhangwan; Liu, Bin; Liu, Jing; Liu, Wen; Lu, Jing; Maheshwari, Manjula; Nguyen, Bao-Viet; Okwuonu, Geoffrey O.; Palmeiri, Anthony; Pasternak, Shiran; Perez, Lesette M.; Phelps, Karen A.; Plopper, Farah J. H.; Qiang, Boqin; Raymond, Christopher; Rodriguez, Ruben; Saenphimmachak, Channakhone; Santibanez, Jireh; Shen, Hua; Shen, Yan; Subramanian, Sandhya; Tabor, Paul E.; Verduzco, Daniel; Waldron, Lenee; Wang, Jian; Wang, Jun; Wang, Qiaoyan; Williams, Gabrielle A.; Wong, Gane K.-S.; Yao, Zhijian; Zhang, JingKun; Zhang, Xiuqing; Zhao, Guoping; Zhou, Jianling; Zhou, Yang; Contributors, Further; Nelson, David; Lehrach, Hans; Reinhardt, Richard; Naylor, Susan L.; Yang, Huanming; Olson, Maynard; Weinstock, George; Gibbs, Richard A.

The DNA sequence, annotation and analysis of human chromosome 3

Donna M. Muzny, Steven E. Scherer (), Rajinder Kaul, Jing Wang, Jun Yu, Ralf Sudbrak, Christian J. Buhay, Rui Chen, Andrew Cree, Yan Ding, Shannon Dugan-Rocha, Rachel Gill, Preethi Gunaratne, R. Alan Harris, Alicia C. Hawes, Judith Hernandez, Anne V. Hodgson, Jennifer Hume, Andrew Jackson, Ziad Mohid Khan, Christie Kovar-Smith, Lora R. Lewis, Ryan J. Lozado, Michael L. Metzker, Aleksandar Milosavljevic, George R. Miner, Margaret B. Morgan, Lynne V. Nazareth, Graham Scott, Erica Sodergren, Xing-Zhi Song, David Steffen, Sharon Wei, David A. Wheeler, Mathew W. Wright, Kim C. Worley, Ye Yuan, Zhengdong Zhang, Charles Q. Adams, M. Ali Ansari-Lari, Mulu Ayele, Mary J. Brown, Guan Chen, Zhijian Chen, James Clendenning, Kerstin P. Clerc-Blankenburg, Runsheng Chen, Zhu Chen, Clay Davis, Oliver Delgado, Huyen H. Dinh, Wei Dong, Heather Draper, Stephen Ernst, Gang Fu, Manuel L. Gonzalez-Garay, Dawn K. Garcia, Will Gillett, Jun Gu, Bailin Hao, Eric Haugen, Paul Havlak, Xin He, Steffen Hennig, Songnian Hu, Wei Huang, Laronda R. Jackson, Leni S. Jacob, Susan H. Kelly, Michael Kube, Ruth Levy, Zhangwan Li, Bin Liu, Jing Liu, Wen Liu, Jing Lu, Manjula Maheshwari, Bao-Viet Nguyen, Geoffrey O. Okwuonu, Anthony Palmeiri, Shiran Pasternak, Lesette M. Perez, Karen A. Phelps, Farah J. H. Plopper, Boqin Qiang, Christopher Raymond, Ruben Rodriguez, Channakhone Saenphimmachak, Jireh Santibanez, Hua Shen, Yan Shen, Sandhya Subramanian, Paul E. Tabor, Daniel Verduzco, Lenee Waldron, Jian Wang, Jun Wang, Qiaoyan Wang, Gabrielle A. Williams, Gane K.-S. Wong, Zhijian Yao, JingKun Zhang, Xiuqing Zhang, Guoping Zhao, Jianling Zhou, Yang Zhou, Further Contributors, David Nelson, Hans Lehrach, Richard Reinhardt, Susan L. Naylor, Huanming Yang (), Maynard Olson, George Weinstock and Richard A. Gibbs
Additional contact information
Donna M. Muzny: Baylor College of Medicine
Steven E. Scherer: Baylor College of Medicine
Rajinder Kaul: University of Washington Genome Center
Jing Wang: Chinese Academy of Sciences
Jun Yu: Chinese Academy of Sciences
Ralf Sudbrak: Max Planck Institute for Molecular Genetics
Christian J. Buhay: Baylor College of Medicine
Rui Chen: Baylor College of Medicine
Andrew Cree: Baylor College of Medicine
Yan Ding: Baylor College of Medicine
Shannon Dugan-Rocha: Baylor College of Medicine
Rachel Gill: Baylor College of Medicine
Preethi Gunaratne: Baylor College of Medicine
R. Alan Harris: Baylor College of Medicine
Alicia C. Hawes: Baylor College of Medicine
Judith Hernandez: Baylor College of Medicine
Anne V. Hodgson: Baylor College of Medicine
Jennifer Hume: Baylor College of Medicine
Andrew Jackson: Baylor College of Medicine
Ziad Mohid Khan: Baylor College of Medicine
Christie Kovar-Smith: Baylor College of Medicine
Lora R. Lewis: Baylor College of Medicine
Ryan J. Lozado: Baylor College of Medicine
Michael L. Metzker: Baylor College of Medicine
Aleksandar Milosavljevic: Baylor College of Medicine
George R. Miner: Baylor College of Medicine
Margaret B. Morgan: Baylor College of Medicine
Lynne V. Nazareth: Baylor College of Medicine
Graham Scott: Baylor College of Medicine
Erica Sodergren: Baylor College of Medicine
Xing-Zhi Song: Baylor College of Medicine
David Steffen: Baylor College of Medicine
Sharon Wei: Baylor College of Medicine
David A. Wheeler: Baylor College of Medicine
Mathew W. Wright: University College London
Kim C. Worley: Baylor College of Medicine
Ye Yuan: Baylor College of Medicine
Zhengdong Zhang: Baylor College of Medicine
Charles Q. Adams: Baylor College of Medicine
M. Ali Ansari-Lari: Baylor College of Medicine
Mulu Ayele: Baylor College of Medicine
Mary J. Brown: Baylor College of Medicine
Guan Chen: Baylor College of Medicine
Zhijian Chen: Baylor College of Medicine
James Clendenning: University of Washington Genome Center
Kerstin P. Clerc-Blankenburg: Baylor College of Medicine
Runsheng Chen: Chinese Academy of Sciences
Zhu Chen: Chinese Academy of Sciences
Clay Davis: Baylor College of Medicine
Oliver Delgado: Baylor College of Medicine
Huyen H. Dinh: Baylor College of Medicine
Wei Dong: Chinese Academy of Sciences
Heather Draper: Baylor College of Medicine
Stephen Ernst: University of Washington Genome Center
Gang Fu: Chinese Academy of Sciences
Manuel L. Gonzalez-Garay: Baylor College of Medicine
Dawn K. Garcia: University of Texas Health Science Center at San Antonio
Will Gillett: University of Washington Genome Center
Jun Gu: Chinese Academy of Sciences
Bailin Hao: Chinese Academy of Sciences
Eric Haugen: University of Washington Genome Center
Paul Havlak: Baylor College of Medicine
Xin He: University of Texas Health Science Center at San Antonio
Steffen Hennig: RZPD German Resource Center for Genome Research
Songnian Hu: Chinese Academy of Sciences
Wei Huang: Chinese Academy of Sciences
Laronda R. Jackson: Baylor College of Medicine
Leni S. Jacob: Baylor College of Medicine
Susan H. Kelly: Baylor College of Medicine
Michael Kube: Max Planck Institute for Molecular Genetics
Ruth Levy: University of Washington Genome Center
Zhangwan Li: Baylor College of Medicine
Bin Liu: Chinese Academy of Sciences
Jing Liu: Baylor College of Medicine
Wen Liu: Baylor College of Medicine
Jing Lu: Baylor College of Medicine
Manjula Maheshwari: Baylor College of Medicine
Bao-Viet Nguyen: Baylor College of Medicine
Geoffrey O. Okwuonu: Baylor College of Medicine
Anthony Palmeiri: University of Washington Genome Center
Shiran Pasternak: Baylor College of Medicine
Lesette M. Perez: Baylor College of Medicine
Karen A. Phelps: University of Washington Genome Center
Farah J. H. Plopper: Baylor College of Medicine
Boqin Qiang: Chinese Academy of Sciences
Christopher Raymond: University of Washington Genome Center
Ruben Rodriguez: University of Texas Health Science Center at San Antonio
Channakhone Saenphimmachak: University of Washington Genome Center
Jireh Santibanez: Baylor College of Medicine
Hua Shen: Baylor College of Medicine
Yan Shen: Chinese Academy of Sciences
Sandhya Subramanian: University of Washington Genome Center
Paul E. Tabor: Baylor College of Medicine
Daniel Verduzco: Baylor College of Medicine
Lenee Waldron: Baylor College of Medicine
Jian Wang: Chinese Academy of Sciences
Jun Wang: Chinese Academy of Sciences
Qiaoyan Wang: Baylor College of Medicine
Gabrielle A. Williams: Baylor College of Medicine
Gane K.-S. Wong: Chinese Academy of Sciences
Zhijian Yao: Chinese Academy of Sciences
JingKun Zhang: Baylor College of Medicine
Xiuqing Zhang: Chinese Academy of Sciences
Guoping Zhao: Chinese Academy of Sciences
Jianling Zhou: Baylor College of Medicine
Yang Zhou: University of Washington Genome Center
David Nelson: Baylor College of Medicine
Hans Lehrach: Max Planck Institute for Molecular Genetics
Richard Reinhardt: Max Planck Institute for Molecular Genetics
Susan L. Naylor: University of Texas Health Science Center at San Antonio
Huanming Yang: Chinese Academy of Sciences
Maynard Olson: University of Washington Genome Center
George Weinstock: Baylor College of Medicine
Richard A. Gibbs: Baylor College of Medicine

Nature, 2006, vol. 440, issue 7088, 1194-1198

Abstract: Abstract After the completion of a draft human genome sequence1, the International Human Genome Sequencing Consortium has proceeded to finish2 and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B3. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion.

Date: 2006
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DOI: 10.1038/nature04728

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