A small-molecule screen in C. elegans yields a new calcium channel antagonist

Trevor C. Y. Kwok, Nicole Ricker, Regina Fraser, Allen W. Chan, Andrew Burns, Elise F. Stanley, Peter McCourt, Sean R. Cutler and Peter J. Roy ()
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Trevor C. Y. Kwok: University of Toronto
Nicole Ricker: University of Toronto
Regina Fraser: University of Toronto
Allen W. Chan: University of Toronto
Andrew Burns: University of Toronto
Elise F. Stanley: University of Toronto
Peter McCourt: University of Toronto
Sean R. Cutler: University of Toronto
Peter J. Roy: University of Toronto

Nature, 2006, vol. 441, issue 7089, 91-95

Abstract: C. elegans passes screen test A screen for new small-molecules that induce defects in the nematode C. elegans has led to the discovery of a novel 1,4-dihydropyridine (DHP), called nemadipine-A. DHPs antagonize L-type calcium channels and some are used as drugs to treat hypertension, angina, migraine and heart failure. These results suggest the C. elegans model can play an important role in work on drug discovery and analysis.

Date: 2006
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DOI: 10.1038/nature04657

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