A distal enhancer and an ultraconserved exon are derived from a novel retroposon

Gill Bejerano (), Craig B. Lowe, Nadav Ahituv, Bryan King, Adam Siepel, Sofie R. Salama, Edward M. Rubin, W. James Kent and David Haussler
Additional contact information
Gill Bejerano: University of California Santa Cruz
Craig B. Lowe: University of California Santa Cruz
Nadav Ahituv: DOE Joint Genome Institute
Bryan King: University of California Santa Cruz
Adam Siepel: University of California Santa Cruz
Sofie R. Salama: University of California Santa Cruz
Edward M. Rubin: DOE Joint Genome Institute
W. James Kent: University of California Santa Cruz
David Haussler: University of California Santa Cruz

Nature, 2006, vol. 441, issue 7089, 87-90

Abstract: A gene with a past Evidence from vertebrate genome sequences has shown that conserved noncoding regions significantly outnumber coding regions, and that these elements are mostly involved in gene regulation. The origins of these elements are largely unknown, but the availability of the sequence of part of the genome of the Indian coelacanth ‘living fossil’ fish can help track their evolutionary history. One group of these conserved genomic elements has now been identified as originating from a novel short interspersed element (SINE) family of retroposons active 410 million years ago in lobed-finned fishes, and still active today in the coelacanth. Some have acquired function in mammals, with one acting as an enhancer for expression of a neurodevelopmental gene, ISL1, and another as an exon in the mRNA processing gene, PCBP2.

Date: 2006
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DOI: 10.1038/nature04696

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