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The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends

Jonne Helenius, Gary Brouhard, Yannis Kalaidzidis, Stefan Diez and Jonathon Howard ()
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Jonne Helenius: Max Planck Institute of Molecular Cell Biology and Genetics
Gary Brouhard: Max Planck Institute of Molecular Cell Biology and Genetics
Yannis Kalaidzidis: Max Planck Institute of Molecular Cell Biology and Genetics
Stefan Diez: Max Planck Institute of Molecular Cell Biology and Genetics
Jonathon Howard: Max Planck Institute of Molecular Cell Biology and Genetics

Nature, 2006, vol. 441, issue 7089, 115-119

Abstract: Single-molecule microscopy reveals that the kinesin-13 protein MCAK undergoes a one-dimensional random walk on the microtubule surface, unlike the unidirectional movement of other kinesins.

Date: 2006
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DOI: 10.1038/nature04736

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