A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting

Olivier Namy, Stephen J. Moran, David I. Stuart, Robert J. C. Gilbert () and Ian Brierley ()
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Olivier Namy: University of Cambridge
Stephen J. Moran: Henry Wellcome Building for Genomic Medicine, University of Oxford
David I. Stuart: Henry Wellcome Building for Genomic Medicine, University of Oxford
Robert J. C. Gilbert: Henry Wellcome Building for Genomic Medicine, University of Oxford
Ian Brierley: University of Cambridge

Nature, 2006, vol. 441, issue 7090, 244-247

Abstract: Tying the pseudoknot Ribosomal frameshifting is a translational mechanism involved in protein synthesis during the replication of many viral pathogens and in cellular genes more generally. A new set of images of an 80S ribosome stalled at an mRNA pseudoknot shows how the pseudoknot manipulates the ribosome into a different reading frame.

Date: 2006
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DOI: 10.1038/nature04735

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