A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth

Seyun Kim, Pauline Wong and Pierre A. Coulombe ()
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Seyun Kim: Departments of Biological Chemistry
Pauline Wong: Departments of Biological Chemistry
Pierre A. Coulombe: Departments of Biological Chemistry

Nature, 2006, vol. 441, issue 7091, 362-365

Abstract: Repaired for action Controlled growth is an important property of cells, used for tissue renewal both at the slow rate associated with basic housekeeping, and the hastened rate needed for tissue repair. Keratin 17, a structural protein found inside epithelial cells, has now been found to participate in the activation of protein synthesis in conditions calling for rapid cell growth. Keratin proteins are building blocks for cytoskeletal fibrous polymers known as keratin intermediate filaments, and believed to help cells resist mechanical trauma. This new finding reveals an unexpected mechanism whereby the cytoskeleton regulates protein synthesis and growth. It has broad implications, since as well as tissue repair, K17 intermediate filaments may be involved in skin development and homeostasis and in diseases such as psoriasis and carcinoma.

Date: 2006
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DOI: 10.1038/nature04659

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