Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site

Christopher R. Trotta (), Sergey V. Paushkin, Meenal Patel, Hong Li and Stuart W. Peltz
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Christopher R. Trotta: PTC Therapeutics
Sergey V. Paushkin: PTC Therapeutics
Meenal Patel: PTC Therapeutics
Hong Li: Institute of Molecular Biophysics, Florida State University
Stuart W. Peltz: PTC Therapeutics

Nature, 2006, vol. 441, issue 7091, 375-377

Abstract: Cleavage of the 5′ site of introns requires an unusual composite active site with the catalytic residues coming from Sen2, and the cation π sandwich coming from Sen34.

Date: 2006
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DOI: 10.1038/nature04741

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