Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang (), Stephen M. Soisson (), Katherine Young, Wesley Shoop, Srinivas Kodali, Andrew Galgoci, Ronald Painter, Gopalakrishnan Parthasarathy, Yui S. Tang, Richard Cummings, Sookhee Ha, Karen Dorso, Mary Motyl, Hiranthi Jayasuriya, John Ondeyka, Kithsiri Herath, Chaowei Zhang, Lorraine Hernandez, John Allocco, Ángela Basilio, José R. Tormo, Olga Genilloud, Francisca Vicente, Fernando Pelaez, Lawrence Colwell, Sang Ho Lee, Bruce Michael, Thomas Felcetto, Charles Gill, Lynn L. Silver, Jeffery D. Hermes, Ken Bartizal, John Barrett, Dennis Schmatz, Joseph W. Becker, Doris Cully and Sheo B. Singh ()
Additional contact information
Jun Wang: Merck Research Laboratories
Stephen M. Soisson: Merck Research Laboratories
Katherine Young: Merck Research Laboratories
Wesley Shoop: Merck Research Laboratories
Srinivas Kodali: Merck Research Laboratories
Andrew Galgoci: Merck Research Laboratories
Ronald Painter: Merck Research Laboratories
Gopalakrishnan Parthasarathy: Merck Research Laboratories
Yui S. Tang: Merck Research Laboratories
Richard Cummings: Merck Research Laboratories
Sookhee Ha: Merck Research Laboratories
Karen Dorso: Merck Research Laboratories
Mary Motyl: Merck Research Laboratories
Hiranthi Jayasuriya: Merck Research Laboratories
John Ondeyka: Merck Research Laboratories
Kithsiri Herath: Merck Research Laboratories
Chaowei Zhang: Merck Research Laboratories
Lorraine Hernandez: Merck Research Laboratories
John Allocco: Merck Research Laboratories
Ángela Basilio: Merck Research Laboratories
José R. Tormo: Merck Research Laboratories
Olga Genilloud: Merck Research Laboratories
Francisca Vicente: Merck Research Laboratories
Fernando Pelaez: Merck Research Laboratories
Lawrence Colwell: Merck Research Laboratories
Sang Ho Lee: Merck Research Laboratories
Bruce Michael: Merck Research Laboratories
Thomas Felcetto: Merck Research Laboratories
Charles Gill: Merck Research Laboratories
Lynn L. Silver: Merck Research Laboratories
Jeffery D. Hermes: Merck Research Laboratories
Ken Bartizal: Merck Research Laboratories
John Barrett: Merck Research Laboratories
Dennis Schmatz: Merck Research Laboratories
Joseph W. Becker: Merck Research Laboratories
Doris Cully: Merck Research Laboratories
Sheo B. Singh: Merck Research Laboratories

Nature, 2006, vol. 441, issue 7091, 358-361

Abstract: New-wave antibiotics The worldwide spread of antibiotic resistance in pathogenic bacteria raises serious concerns that today's front-line antibiotics may become ineffective. So the discovery of a new class of compound with enormous potential as antibiotics is of great interest. Platensimycin is the first member of a novel class of natural products that selectively kills bacteria by inhibiting FabF/FabB proteins, a mechanism of action that is not used by any agents in clinical use. It is a potent antibiotic with broad-spectrum activity against Gram-positive bacteria, including clinically relevant drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. The future of platensimycins is considered in the News pages, and see the antimicrobials Web Focus on http://tinyurl.com/g8omx.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature04784 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:441:y:2006:i:7091:d:10.1038_nature04784

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04784

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().