Toll-like receptors and antibody responses (Reply)

C. Pasare and R. Medzhitov ()
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C. Pasare: Howard Hughes Medical Institute and Section of Immunology, Yale University School of Medicine
R. Medzhitov: Howard Hughes Medical Institute and Section of Immunology, Yale University School of Medicine

Nature, 2006, vol. 441, issue 7091, E4-E4

Abstract: Abstract Using a range of different experimental approaches (and not just analyses of MyD88-deficient mice), we showed that, contrary to the prevailing view, a T-helper response is not sufficient for the generation of optimal T-dependent antibody responses, and that Toll-like-receptor (TLR) signalling in B cells is also required1. Similar results have since been obtained in human B cells2. Nemazee et al .3 now question our conclusions1.

Date: 2006
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DOI: 10.1038/nature04876

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