GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission

Aurélien Roux, Katherine Uyhazi, Adam Frost and Pietro De Camilli ()
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Aurélien Roux: Howard Hughes Medical Institute, Kavli Institute for Neuroscience
Katherine Uyhazi: Howard Hughes Medical Institute, Kavli Institute for Neuroscience
Adam Frost: Boyer Center for Molecular Medicine, Yale University School of Medicine
Pietro De Camilli: Howard Hughes Medical Institute, Kavli Institute for Neuroscience

Nature, 2006, vol. 441, issue 7092, 528-531

Abstract: Dynamic light microscopy imaging of dynamin-coated lipid tubules revealed a GTP hydrolysis-dependent twisting activity — the constricting activity produced by this twisting led to fission only when coupled to the longitudinal tension of the tubules.

Date: 2006
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DOI: 10.1038/nature04718

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