Somatic stem cell niche tropism in Wolbachia

Horacio M. Frydman (), Jennifer M. Li, Drew N. Robson and Eric Wieschaus
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Horacio M. Frydman: Howard Hughes Medical Institute
Jennifer M. Li: Howard Hughes Medical Institute
Drew N. Robson: Princeton University
Eric Wieschaus: Howard Hughes Medical Institute

Nature, 2006, vol. 441, issue 7092, 509-512

Abstract: A niche fit for Wolbachia Wolbachia are remarkably successful intracellular parasites. They are found in most Arthropods and are also in the news as possible tools for malaria control — transgenic variants could block maturation of malaria parasites in mosquitoes. Like mitochondria, these bacteria are transmitted by the mother. They also spread horizontally between species, but little is known about the cellular mechanisms involved. Frydman et al. now report that Wolbachia can cross tissue barriers to reach the germline. They preferentially populate the somatic stem cell niche of the Drosophila germarium (where the ova form) in newly initiated or inherited infections. The stem cell niche appears to act as a reservoir of bacteria for germline infection.

Date: 2006
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DOI: 10.1038/nature04756

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