Nuclear factor-κB in cancer development and progression

Michael Karin ()
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Michael Karin: Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine

Nature, 2006, vol. 441, issue 7092, 431-436

Abstract: Abstract Nuclear factor-κB (NF-κB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-κB signalling also has a critical role in cancer development and progression. NF-κB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-κB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

Date: 2006
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DOI: 10.1038/nature04870

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